Saturday, December 24, 2005

Inside the Corpus Callosum

Cover image: Myelination by galactocerebrosidase-deficient oligodendrocytes transplanted in the corpus callosum of the myelin-deficient shiverer mouse. Provided with the missing lysosomal enzyme, mutant oligodendrocytes (green) derived from the twitcher mouse, a model of globoid cell leukodystrophy (Krabbe's disease), survive and maintain stable myelin (red) wrapping of naked host axons. See the article by Kondo et al. on pages 18670–18675. Image courtesy of Yoichi Kondo.