Wednesday, March 03, 2004

What Happens When the Corpus Callosum is Too Small
An Explanation for Compulsive Blogging?

From: PubMed

J Child Neurol. 2002 Jul;17(7):535-7. Related Articles, Links

Hypoplasia of the corpus callosum and obsessive-compulsive symptoms.

Farchione TR, Lorch E, Rosenberg DR.

Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

Abnormalities in the corpus callosum, which connects the cerebral hemispheres, have been implicated in the pathogenesis of obsessive-compulsive disorder. This is a report of two cases of obsessive-compulsive disorder associated with hypoplasia of the corpus callosum. These data provide further support for corpus callosum-mediated dysfunction in obsessive-compulsive disorder.

What Happens When the Corpus Callosum is Too Small
An Explanation for Attention Deficit Disorder?

From: Medscape

Attention Deficit Hyperactivity Disorder: Current Diagnosis and Treatment

Mark L. Wolraich, MD  

Although ADHD remains a heterogeneous condition for which no one etiology has emerged, there has been growing evidence for the explanation that the condition is caused by a complex interaction between biologic and environmental factors -- a phenomenon similar to that of other mental disorders, such as depression and anxiety. There is evidence that both morphologic and functional brain differences are present in individuals with ADHD compared to a normative sample. Individuals with ADHD have a consistent but moderate reduction in average size of the corpus callosum, basal ganglia (caudate and globus pallidus), and frontal lobes, compared with normal controls.[7-10] Functionally, there is striatal hypoperfusion in individuals with ADHD compared with normal controls.[11-13]